Our team focuses on cancer epigenetics with the aim to understand the role of epigenetic changes in
cancer development and progression and associate these changes with genetics modifications.
Methods and techniques we develop for the analysis of cancer genomes and epigenomes can be applied to most of the cancer types. Currently, we are interested in understanding the oncogenic processes related to several cancer types: neuroblastoma, adrenocortical carcinoma, melanoma, MDS and CMML. But we are open to collaborations with research groups studying other types of cancer.
We aim at addressing the following questions:
- Determine the role of epigenetic remodeling in oncogenic transformation
- Investigate the consequences of somatic genomic alterations on the epigenetic landscape in cancer
- Adjust methodology for studying genetic and epigenetic changes in cancer
Methods and techniques we develop for the analysis of cancer genomes and epigenomes can be applied to most of the cancer types. Currently, we are interested in understanding the oncogenic processes related to several cancer types: neuroblastoma, adrenocortical carcinoma, melanoma, MDS and CMML. But we are open to collaborations with research groups studying other types of cancer.
Methodogological development by the members of the lab includes methods for:
- ChIP-seq data analysis: transcription factors, histone modifications in normal and cancer cells
- Analysis of whole genome / whole exome / target sequencing data: detection of copy number alterations and structural variants
- Analysis of clonal heterogeneity in cancer
- Analysis of cancer RNA-seq: detection of abnormal transcripts expressed in cancer cells
Check the whole list of the developed software.
Complete list of publications: Link
We offer several internship projects to bachelor and masters students. Please check this page for more information!