
This page is for the Genomic Regulation 2018:
General information
Genomic Regulation 2018 is intended to provide a forum to discuss recent advances in the field of regulation of transcription in the living organisms. We will gather scientists working in both bioinformatics and experimental biology, addressing diverse aspects of transcriptional regulation in normal and pathological conditions. This symposium will allow for fruitful scientific discussions and exchange of ideas. Sharing recent discoveries among high profile scientists will advance our understanding of the mechanisms of gene expression regulation, convey new concepts and result in novel international collaborations.
Invited speakers
- Albin Sandelin, Copenhagen University, Denmark
- Alena Shkumatava, Institut Curie, France
- Artemis Hatzigeorgiou, University of Thessaly, Greece
- Bart Deplancke, SIB & EPFL, Switzerland
- Christina Leslie, MSKCC, USA
- Erik van Nimwegen, SIB & University of Basel, Switzerland
- Ewa Szczurek, University of Warsaw, Poland
- Fran Supek, IRB Barcelona, Spain
- Jose Luis Gomez Skarmeta, University Pablo Olavide, Spain
- Julien Gagneur, TU Munich, Germany
- Martin Vingron, Max Planck Institute, Germany
- Nicholas Luscombe, UCL and Francis Crick Institute, UK
- Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine and Charite, Germany
- Paul Flicek, EBI, UK
- Peter Kharchenko, Harvard Medical School, USA
- Raluca Gordan, Duke University, USA
Meeting Program
Thursday Mar 15
18:00 – 22:00 Arrival and Registration
19:00 Dinner at the Hotel
Friday Mar 16 Morning Session
08:30-10:15 Session 1: Epigenetics and Transcriptional Regulation
Valentina Boeva: Getting insights into cancer biology using the analysis of epigenetic data
Erik van Nimwegen: Inferring epigenergy landscapes from single-cell RNA-seq data
Peter Kharchenko:
Exploring human brain with single-cell transcriptional and epigenetic
measurements
10:15-10:35 Coffee break
10:35-12:00 Session 2: Design Principles and Evolution of cis-Regulatory Modules and Networks
Paul Flicek: Evolution of mammalian tissue specific transcriptional regulation
Jose Luis Gomez Skarmeta: Evolution of regulatory landscapes
Masa Roller*: Tissue-specific enhancer and promoter evolution in mammals
Friday Mar 16 Evening Session
16:30-17:30 Coffee and snacks – posters
17:30-19:45 Session 3: Sequence, Structure and Function of Enhancers and Promoters
Martin Vingron: Epigenetic networks, enhancer recognition and differential enhancers
Philipp Bucher: Structure and Evolution of Eukaryotic Core Promoter Elements
René Dreos*: Comparative analysis of core promoter elements using an EM algorithm
Uwe Ohler: Determinants of transcription directionality across metazoans
Dubravka Vucicevic*: Functional dissection of enhancers involved in neurogenesis using CRISPR/Cas9
Christ Leemans*: Mechanisms of gene regulation in lamina - associated domains
20:00 Dinner at the Hotel
Saturday Mar 17 Morning Session
08:30-10:15 Session 4: Regulation of Gene Expression by Signaling Pathways and RNA
Denis Thieffry: Synergy between T cell receptor and Toll-like receptor 5 signalling for CD4+ T cell activation
Tamar Juven-Gershon: Drosophila TBP-related factor 2 is a unique basal transcription factor that drives the expression of multiple target genes to regulate cell cycle progression and viability
Nikolaus Rajewsky: Single Cell Approaches for Understanding Gene Regulation by RNA
10:15-10:35 Coffee break
10:35-12:00 Session 5: Modeling the Evolution and Consequences of Regulatory Mutations in Human Disease
Albin Sandelin: The promoter- and enhancer landscape of inflammatory bowel disease
Fran Supek: Cancer genomes reveal clustered mutation signatures of error-prone DNA repair in active chromatin
Juan J. Tena*: Uncovering novel targets for p63-related hereditary malformations
Saturday Mar 17 Evening Session
16:30-17:30 Coffee and snacks – posters
17:30-19:45 Session 6: Experimental Characterization and Computational Modeling of Regulatory interactions
Raluca Gordan: New insights into protein-DNA recognition: binding specificity to mispaired DNA, and divergence in specificity within transcription factor families
Bart Deplancke: Understanding human molecular variation using variable chromatin modules
Ewa Szczurek: Generalizations of linear effects models of signaling pathways from combinatorial perturbation data
Carl Herrmann*: Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers
20:00 Dinner at the Hotel
Sunday Mar 18 Morning Session
08:30-10:15 Session 7: Transcription Initiation and Regulatory RNAs
Boris Lenhard: Turnover of genomic regulatory blocks and evolution of long-range regulation
Alena Shkumatava: Dissecting the in vivo functions and mechanisms of action of lncRNAs
Artemis Hatzigeorgiou: Revisiting CAGE data analysis using structural information and machine learning
10:15-10:35 Coffee break
10:35-12:00 Session 8: Multi-level Genomic Regulation by DNA-binding Transcription Factors
Julien Gagneur: Proteogenomic characterization of human tissues reveals mRNA motifs controlling protein abundance
Pierre-Antoine Defossez: Mechanisms and functions of mammalian proteins that bind methylated DNA
Jake Yeung*: Chromatin interactions and transcription factor activity rhythms orchestrate circadian gene expression across organs
* Talks from selected abstracts
Participants:
- Alexander Kel
- Aziz Khan
- Bartek Wilczynski
- Carl Herrmann
- Christ Leemans
- Dubravka Vucicevic
- Jake Yeung
- Jonas Ibn-Salem
- Juan J. Tena
- Martin Burkert
- Masa Roller
- René Dreos
- Stephany Orjuela
- Swann Floc'hlay
- Tobias Zehnder
- Touati Benoukraf
- Vsevolod Makeev
Organizers
- Boris Lenhard, Imperial College London, UK
- Philipp Bucher SIB & EPFL, Switzerland
- Tammy Juven-Gershon, Bar-Ilan University, Israel
- Uwe Ohler, Max Delbrück Center, Germany
- Valentina Boeva, Inserm & Institut Cochin, France
Dates and Venue
Venue: One of the best hotels in the Swiss Alps: Hotel Nendaz .
We plan to organize morning and evening sessions and leave the afternoon free for mountain activities: skiing, snowboarding and snowshoe hiking at this beautiful ski resort.
Dates: March 15-18, 2017.
Sponsors
Swiss National Science Foundation (SNSF)